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neuropixels-analysis

Neuropixels neural recording analysis. Load SpikeGLX/OpenEphys data, preprocess, motion correction, Kilosort4 spike sorting, quality metrics, Allen/IBL curation, AI-assisted visual analysis, for Neuropixels 1.0/2.0 extracellular electrophysiology. Use when working with neural recordings, spike sorting, extracellular electrophysiology, or when the user mentions Neuropixels, SpikeGLX, Open Ephys, Kilosort, quality metrics, or unit curation.

5,913stars710forksUpdated 1/15/2026

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About neuropixels-analysis

The neuropixels-analysis skill is a comprehensive toolkit designed for the analysis of high-density neural recordings obtained through Neuropixels technology. This skill addresses the challenges of handling complex neural data, streamlining the workflow from raw data acquisition to the generation of publication-ready results. By integrating advanced preprocessing techniques, spike sorting algorithms, and quality metrics, this skill enhances the accuracy and efficiency of neural data analysis, making it indispensable for researchers in the field of electrophysiology.

FAQ

What types of data can I load using neuropixels-analysis?

You can load data from SpikeGLX (.ap.bin, .lf.bin, .meta), Open Ephys (.continuous, .oebin), and NWB (.nwb) formats.

Is there a specific hardware requirement for using this skill?

Yes, the skill supports Neuropixels 1.0 and 2.0 probes with specific channel configurations.

Can I perform spike sorting with this skill?

Yes, this skill supports several spike sorting algorithms, including Kilosort4, SpykingCircus2, and Mountainsort5.

What preprocessing steps are recommended before spike sorting?

Recommended preprocessing includes high-pass filtering, phase shift correction for Neuropixels 1.0, bad channel detection, and common reference adjustment.

Is there any limitation on the type of recordings I can analyze?

The skill is specifically designed for Neuropixels recordings and may not be suitable for other types of neural recording systems.

Install neuropixels-analysis

Download and extract the skill files to your .claude/skills/ directory.

Quick Setup:

  1. Copy the skill folder to .claude/skills/
  2. Claude will automatically detect and use the skill