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reactome-database

Query Reactome REST API for pathway analysis, enrichment, gene-pathway mapping, disease pathways, molecular interactions, expression analysis, for systems biology studies.

17,798stars1,609forksUpdated 1/21/2026

Security Assessment

High Risk(40/100)

Detected risks:

Data Exfiltration([SKILL.md] requests.post)
Secret Exposure([SKILL.md] token =)
Security Score40/100

About reactome-database

The Reactome Database skill provides users with the ability to query the Reactome REST API for comprehensive pathway analysis and enrichment. This skill addresses the need for researchers and scientists to analyze biological pathways in a systematic manner, offering access to over 2,825 curated human pathways. By utilizing this skill, users can perform various analyses, such as overrepresentation analysis, expression analysis, and gene-pathway mapping, thus enabling a deeper understanding of molecular interactions and biological processes relevant to their studies.

FAQ

What types of analyses can I perform using this skill?

You can perform pathway enrichment analysis, gene expression analysis, query specific pathway information, and map genes or proteins to biological pathways.

Is the reactome2py Python package actively maintained?

The reactome2py package (version 3.0.0) is functional but not actively maintained. It's recommended to use direct REST API calls for the most up-to-date functionality.

What formats does the Content Service return data in?

The Content Service returns data in JSON or plain text formats.

Can I compare pathway data across different organisms?

Yes, the Analysis Service allows for species comparison of pathway data.

How do I install the reactome2py package?

You can install the reactome2py package using the command: uv pip install reactome2py.

Install reactome-database

Download and extract the skill files to your .claude/skills/ directory.

Quick Setup:

  1. Copy the skill folder to .claude/skills/
  2. Claude will automatically detect and use the skill