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cobrapy

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

17,798stars1,609forksUpdated 1/21/2026

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About cobrapy

COBRApy is a Python library specifically designed for constraint-based reconstruction and analysis (COBRA) of metabolic models, addressing the challenges faced in systems biology research. It enables researchers to work with genome-scale metabolic models, conduct computational simulations of cellular metabolism, and perform metabolic engineering analyses. By facilitating the prediction of phenotypic behaviors, COBRApy provides essential tools for understanding and manipulating metabolic pathways, ultimately aiding in the development of biotechnological applications and therapeutic strategies.

FAQ

What types of models can be loaded into COBRApy?

COBRApy can load models from various formats including SBML, JSON, and YAML, as well as bundled test models.

Is COBRApy compatible with Python 3?

Yes, COBRApy is designed to be used with Python, and it is recommended to use Python 3 for optimal compatibility.

What are the main analyses that can be performed using COBRApy?

COBRApy supports various analyses including Flux Balance Analysis (FBA), Flux Variability Analysis (FVA), and gene and reaction deletion studies.

Are there any limitations to the types of analyses COBRApy can perform?

The limitations mainly depend on the complexity of the metabolic model being analyzed and the computational resources available.

Can I perform multi-threaded analyses with COBRApy?

Yes, COBRApy allows for multi-threaded analyses, particularly in double gene and reaction deletion studies.

Install cobrapy

Download and extract the skill files to your .claude/skills/ directory.

Quick Setup:

  1. Copy the skill folder to .claude/skills/
  2. Claude will automatically detect and use the skill